Since the prolonged release of adv from the adv@Nap gel, combined with the induction of adaptive antitumor immune responses, especially cytotoxic effects, as well as central memory CD8+ T cells, has been confirmed in vitro and in vivo, we evaluated the ability of the adv@Nap gel to prevent tumor recurrence following resection in a mouse model of breast cancer. Here, CD8A is linked to breast carcinoma.