TNF and type 2 diabetes mellitus: Sun et al. [226] administered TARM at 400 mg/kg to T2DM mice reduced body weight and serum lipid levels (TG and TC), downregulated inflammatory factors (IL-6, TNF-α, MCP-1, F4/80) in adipose tissue, and upregulated anti-inflammatory cytokines (IL-4, IL-10, IL-13), highlighting its potential in regulating lipid metabolism and alleviating adipose inflammation.