TNF and rheumatoid arthritis: Cytokine storm is a potentially fatal condition characterized by the uncontrolled and increased release of cytokines that promote inflammation, such as interleukin IL-1β, IL-6, tumor necrosis factor-alpha (TNF-α), etc. It is associated with various diseases that might lead to death, including chronic hepatitis, rheumatoid arthritis, colon cancer, atherosclerosis, multiple sclerosis, and inflammatory bowel disease (IBD) [52].