Meanwhile, deficiency of circRNA-14,052 led to a significant decrease in circRNA-14,052, IKBKB, IL-6, JAK2, and STAT3 levels, and an increase in miR-214-3p levels in tumor tissues from MCF-7 tumor-bearing mice compared to the LV-NC group (Fig. 8A-G). The gene discussed is IL6; the disease is neoplasm.