(2009) demonstrated that there are two important types of MDE - membrane-bound and diffusible metalloproteinases - involved in cancer invasion and their study focussed on the membrane-bound membrane-type-1 matrix metalloproteinase (MT1-MMP) and the diffusible (soluble) matrix metalloproteinase-2 (MMP-2), and their interactions with the extracellular matrix. This evidence concerns the gene MMP2 and cancer.