Whilst the OR of PTV burden in BRCA2 and PALB2 for breast cancer remained broadly consistent between screening- and interval-detected cancers, PTV burden in both RAD51C and BRCA1 had a markedly greater effect size and strength of association for interval-detected cancers (vs controls) than screen-detected cancers (Supplementary Data items 12–15). Here, PALB2 is linked to breast cancer.