Indeed, expression of GATA3 and pan (type I) keratin was also markedly decreased in STP tumors by 3.5 months after tamoxifen treatment, consistent with loss of PAX8 (Supplementary Fig. 8E) and STK, STP and PTK transgenic kidneys showed significant enrichment of both up- and downregulated genes from renal TSC-related PEComas compared to controls (Fig. 5G)36. This evidence concerns the gene PAX8 and neoplasm with perivascular epithelioid cell differentiation.