TFE3 and neoplasm: Following induction of SFPQ-TFE3 expression with tamoxifen, we treated male and female cohorts of mice with vehicle or Torin1 for 4 weeks, following which kidney FFPE sections were immunostained for p-S6 to confirm mTORC1 inhibition (Supplementary Fig. 11A) and GPNMB to quantify tumor area in digital whole slide images of kidney (Supplementary Fig. 11B).