PTK2B and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Notably, the core set of differentially expressed genes overlapping between human tRCC and the ASPSCR1-TFE3 mouse model26 was strikingly enriched in the STP, STK, and PTK transgenic kidney tumors (Supplementary Fig. 7A), highlighting the transcriptional overlap between our mouse models and tRCC.