TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Here, we describe a transgenic mouse model of renal tumorigenesis induced by SFPQ-TFE3 expression, the most common TFE3 gene fusion seen in human PEComas and their melanotic variants3,10,31, and the last of the three most common tRCC fusions that has yet to be modeled in mice.