We then examined RRAGC and RRAGD gene expression in the aforementioned panel of 8 UOK tRCC cell lines, and confirmed increased expression of both genes, most notably RRAGD, compared to clear cell RCC control cell lines (Supplementary Fig. 5B, C), with similar findings at the protein level by immunoblot (Supplementary Fig. 5D). The gene discussed is RRAGD; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.