PAX8 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Pathologically, the key distinction between tRCC and MiT/TFE-driven renal PEComas is the lack of apparent epithelial differentiation in the latter, as evidenced by the complete absence of pan-epithelial markers (cytokeratins/EMA/CD10)7 and loss of critical renal lineage transcription factors, PAX8 and PAX28–10.