Furthermore, in tRCC, in addition to RRAGD, multiple regulators of lysosomal mTORC1 signaling (RHEB53, RRAGB26, RRAGC26,53FNIP1/226), are also transcriptionally activated, suggesting a more complex mechanism of mTORC1 activation may be at work. This evidence concerns the gene RRAGD and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.