A more heterogeneous pattern of PAX8 and PAX2 suppression was seen in the STK kidneys at P15 (Fig. 5C) as well as the PTK kidney tumors at 7 months age (Fig. 5D) however these differences were highly significant on digital quantification for PAX8 IHC expression (Fig. 5E, F), indicating that both SFPQ-TFE3 and PRCC-TFE3 expression drives varying degrees of renal lineage factor loss in the murine kidney. The gene discussed is PAX8; the disease is kidney neoplasm.