Notably, the core set of differentially expressed genes overlapping between human tRCC and the ASPSCR1-TFE3 mouse model26 was strikingly enriched in the STP, STK, and PTK transgenic kidney tumors (Supplementary Fig. 7A), highlighting the transcriptional overlap between our mouse models and tRCC. Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.