Since SFPQ-TFE3 expression is limited to PAX8-expressing cells in the STP model due to use of the Pax8-CreERT model, this model serves as a lineage tracing experiment, thereby substantiating renal tubular epithelial cells as the cell of origin for a TFE3 fusion-driven murine PEComa model. Here, PAX8 is linked to neoplasm with perivascular epithelioid cell differentiation.