The expression level of WNT2 was significantly lower in tumors than in the corresponding normal tissues, including CESC, HNSC-HPV positive, KIRP (P < 0.05), GBM, UCEC (P < 0.01), KIRC, LIHC, LUAD, LUSC, PRAD, and THCA (P < 0.001), than in the corresponding control tissues. The gene discussed is WNT2; the disease is glioblastoma.