To better understand the differential response to ZIKV infection, we analyzed the transcriptional signature of the placenta exposed to ZIKV infection and observed that at the transcriptomic level, male placentas were enriched for pathways related to innate immune responses, including IFN-β signaling, regulation of IL-1β production, and neutrophil activity. The gene discussed is IFNB1; the disease is Zika virus infectious disease.