MTCH2 and obesity due to melanocortin 4 receptor deficiency: The MTCH2 expression was significantly higher in both scWAT and visceral WAT (visWAT) from individuals living with obesity (BMI ≥ 30) compared to lean individuals (BMI < 30) (Fig. 2b), suggesting the relevance of MTCH2 to WAT in the context of obesity, which is consistent with previous studies34,38.