MCRS1 and cirrhosis of liver: For example, inducible hepatocyte-specific knockout of Kat8 in adult mice showed no effect on hepatocyte function (Lei et al, 2021), whereas deletion of Mcrs1 in hepatocytes results in severe liver cirrhosis and lethality within 3 wk post-induction because of accumulation of bile acids in the hepatic sinusoids (Garrido et al, 2022).