To determine the relative efficacy of different bile acids to modulate gut-liver NR1H4-FGF19 signaling, we measured serum markers of cholestasis and bile acid pools in TPN-fed pigs given enteral CDCA (30 mg/kg) or OCA (0.5, 5, or 15 mg/kg) for 19 days. The gene discussed is FGF19; the disease is cholestasis.