The results revealed significant expression changes of many genes involved in generating APs in ALS iMNs (Figure 2D), particularly subunits of voltage-gated sodium channels (e.g., SCN2A), subunits of voltage-gated potassium channels (e.g., KCNQ1 and KCNA1), and catalytic subunits of Na+/K+-ATPase (e.g., ATP1A3 and ATP1A2). Here, ATP1A3 is linked to amyotrophic lateral sclerosis.