To determine which factors predominantly mediate TCF-1 downregulation during acute infection, a mixture of congenically distinct WT and Tcf7ΔAICE−22, Tcf7ΔEbox−22, or Tcf7ΔBlimp1−22 P14 cells was adoptively transferred to naive recipients, and their spleens were analyzed 8 dpi with LCMV-Arm (Figure 5G). This evidence concerns the gene TCF7 and infection.