To prove that apyrase effect was not restricted to C57BL/6 genetic background, we engrafted CT26 colon carcinoma in BALB/c mice, which are known to display a different microbiota and IgA polyreactivity with respect to C57BL/6 mice (33), and treated them as MC38 tumor-bearing mice (Fig. 1A). This evidence concerns the gene CD79A and colon carcinoma.