Whereas the various TCRVβ regions were uniformly expressed in CD8 T cells isolated from the PPs of differently treated mice, a significant increase in TCRVβ6-expressing cells was observed in CD8 TILs from mice treated with anti–PD-L1 and apyrase as compared to mice treated with standalone anti–PD-L1, suggesting that particular clonotype/s were selectively enriched within the tumor bed and could eventually confer enhanced control of tumor growth. This evidence concerns the gene CD274 and neoplasm.