SPAG6 and hematopoietic and lymphoid cell neoplasm: For instance, SPAG6 silencing has been shown to suppress the proliferation of malignant myeloid SKM-1 and K562 cells and trigger apoptotic cascades through activation of p53, PTEN, and caspases 3, 8, and 9, suggesting its potential as a prognostic marker in hematologic cancers [18].