Our results have shown that eight active ingredients (luteolin, quercetin, baicalein, ellagic acid, kaempferol, paeoniflorin, cryptotanshinone, tanshinone iia) and five hub targets (MMP9, TNF, IL-6, STAT3, TP53) might be responsible for therapeutic effect of XBJ on sepsis and septic-AKI. Here, IL6 is linked to acute kidney injury.