Multivariate Cox regression analysis revealed that elevated SNHG3 expression could serve as an independent predictor of mortality (hazard ratio [HR] = 1.752, 95% CI: 1.164–2.657, p = 0.008) and disease progression (HR = 7.598, 95% CI: 0.944–61.152, p = 0.037) in prostate cancer. The gene discussed is SNHG3; the disease is prostate carcinoma.