TNC and chronic kidney disease: Another issue is that macrophages may not only promote kidney injury by inciting inflammation, but also directly cause fibrotic lesions by promoting macrophage‐myofibroblast transformation.[43] It is conceivable to speculate that TNC, as the organizer of the fibrotic niche, promotes CKD progression by affecting multiple types of cells, such as fibroblasts, macrophages and tubular cells in a spatially defined fashion.