More advanced stages of MASLD, characterized by inflammation, hepatocyte injury, or fibrosis, are classified as MASH (metabolic dysfunction‐associated steatohepatitis, previous known as non‐alcoholic steatohepatitis).[78] To investigate whether cGAS‐governed lipid droplet formation contributes to MASLD, we treated liver PLC/PRF/5 cells with free fatty acids (FFA; oleic acid:palmitic acid = 2:1), a widely used in vitro MASLD model.[79] Ectopic cGAS expression in PLC/PRF/5 cells suppressed FFA‐induced lipid droplet formation (Figure6A). This evidence concerns the gene CGAS and metabolic dysfunction-associated steatotic liver disease.