To investigate the pathophysiological role of cGAS/ALDH2/lipid droplet signaling in the development of MASLD, we used a modified high‐fat diet (HFD) known to induce MASLD in mice[80] (Research Diet A06071309: a methionine‐ and choline‐deficient diet with 45 kcal% fat). Here, ALDH2 is linked to metabolic dysfunction-associated steatotic liver disease.