Recent studies demonstrated that lipid droplets are induced during infections with the Zika virus and HSV‐1 in an EGFR‐dependent manner.[87] It has also been reported that the formation of lipid droplets following viral infections enhances IFN expression, thereby promoting antiviral defense and limiting viral replication.[87] In our study, we observe that dsDNA disrupts the interaction between cGAS and ALDH2. Here, ALDH2 is linked to viral infectious disease.