METTL5 is the m6A methyltransferase that modifies adenosine 1832 of 18S rRNAs, and this function requires its binding to TRMT112.[24, 58]METTL5‐KO mice are viable but display reduced body size and body fat as shown in two independent studies.[23, 58]Mettl5 KO downregulates the expression of genes involved in lipid biosynthesis and storage.[58] Although there is no obvious cardiac abnormality in METTL5‐KO mice, cardiac‐specific Mettl5 KO was reported to promote stress‐induced cardiac remodeling.[59] Regarding cancer biology, the involvement of METTL5 is mainly studied in HCC. The gene discussed is TRMT112; the disease is cancer.