The complex of METTL3/METTL14 is responsible for around 95% of m6A methylation of mRNAs.[54] METTL3/METTL14 can act as oncogenic proteins by maintaining the stability of chromosomes and telomeres in cancer cells and promoting uncontrolled proliferation.[54] METTL3/METTL14 also enhances the activation of p53 signaling in response to DNA damage by stabilizing p53 protein.[57] Via this mechanism, METTL3/METTL14 exhibits tumor suppressor activity in some contexts. The gene discussed is METTL3; the disease is neoplasm.