METTL5 and hepatocellular carcinoma: The A1832 methylation of 18S rRNA plays a critical role in neural development and lipid metabolism by regulating translation efficiency.[21] Loss‐of‐function mutations or deletion of METTL5 in humans and mice lead to developmental abnormalities.[22, 23] Additionally, increased METTL5 activity is associated with the development of hepatocellular carcinoma.[24] However, the immunological role of METTL5 remains largely unexplored.