METTL5 depletion also has no significant impact on the in vitro growth of HCT116, a p53‐positive colon carcinoma line.[65] Together, these findings suggest that the correlation of METTL5 expression and cancer progression could be variable and dependent on cancer types, which is similar to other METTLs with multifaceted functions.[54]. The gene discussed is TP53; the disease is cancer.