METTL5 and nasopharyngeal carcinoma: Although the absence of Mettl5 in mouse embryonic stem cells and several human nasopharyngeal carcinoma cell lines was reported to result in a decrease in the global translation rate,[23, 63] our ribosome profiling results reveal that translational changes associated with METTL5 knockout are more pronounced in transcripts containing strong Kozak sequences when compared to those lacking them.