HMGCR and diffuse large B-cell lymphoma: At the mechanistic level, cell experiments confirmed that the expression of proteins and enzymes promoting cholesterol absorption and synthesis (CD36, SREBP2 and HMGCR) was elevated in DLBCL cell lines, while the expression of proteins promoting cholesterol efflux (NR1H2, APOA1 and ABCG1) was reduced, collectively driving the proliferation of DLBCL tumor cells.