Previous studies have shown that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with the risk of non-Hodgkin lymphoma (Lim et al., 2007), whereas low serum apolipoprotein A1 (APOA1) levels are significantly correlated with poor prognosis in DLBCL patients (Huang et al., 2024). This evidence concerns the gene APOA1 and diffuse large B-cell lymphoma.