Several cancer types, including basal cell carcinoma, hepatocellular carcinoma, non-small cell lung cancer, cutaneous squamous cell carcinoma, and solid tumors, share two common targets: prostaglandin-endoperoxide synthase 2 (PTGS2) and transforming growth factor beta 1 (TGFB1). This evidence concerns the gene TGFB1 and cutaneous squamous cell carcinoma.