GP-induced histone lactylation drives the progression of metastatic colorectal cancer and promotes the transcription of RUBCNL, which enhances autophagy by promoting autophagosome maturation and maintaining cellular homeostasis; Glycolysis inhibitors can inhibit histone lactylation and enhance the sensitivity of colorectal cancer cells to bevacizumab. The gene discussed is RUBCNL; the disease is metastatic colorectal cancer.