FHC cells use the negative feedback mechanism to involve the lactic acidification-dependent inhibition of the speed-limiting enzyme PFKP in GP. The PFKP lactication in SW480 cells and colon cancer tissue directly attenuates the activity of the enzyme. The distuned lactic acid/la-PFKP negative feedback ring plays an important role in the progression of colon cancer. The gene discussed is PFKP; the disease is malignant colon neoplasm.