HAVCR2 and autoimmune disease: Immune checkpoints such as LAG-3, T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), T cell immunoglobulin and ITIM domain (TIGIT), and V-domain immunoglobulin suppressor of T cell activation (VISTA) are emerging targets for immune modulation and restoring immune tolerance and have been the focus of many studies on autoimmune disease (Figure 2).