T-bet+ hTregs in the peripheral blood of untreated, relapsing-remitting MS (RRMS) patients exhibit higher levels of T-bet, CXCR3, CCR5, and IFN-γ, along with reduced levels of TGF-β and CTLA-4 (19). Here, CXCR3 is linked to relapsing-remitting multiple sclerosis.