TNFRSF4 and neoplasm: To this aim, tumor cells were plated at the density of 10’000/well and incubated with hPBMCs or NK cells (effector: target ratio 5:1) preactivated with SEB (50 ng/mL) for 48 h and then treated with anti-OX-40 mAbs alone or in combination with the validated anti-PD-L1 mAb for 48 h.