During helminth infection, cytosolic phospholipase A2 (cPLA2) in tuft cells liberates arachidonic acid from phospholipids, which is subsequently metabolized by enzymes (e.g., Pla2g4a, Alox5ap, Ltc4s) into leukotrienes that synergize with IL-25 to activate ILC2s through CysLT receptors, thereby amplifying type 2 immune responses (25). This evidence concerns the gene PLA2G4A and helminthiasis.