In addition to CARD9, this review discusses several other genetic factors associated with the susceptibility to fungal infections, including high IgE syndrome (HIES), Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) syndrome, Dendritic cell-associated C-type lectin-1 (Dectin-1) deficiency, STAT1 mutations, and IL-17 mutations. The gene discussed is CARD9; the disease is fungal infectious disease.