CD4 and neoplasm: An increase of conventional CD4+ T cells and NK cells was observed at later timepoints (3.5% of conventional CD4 T cells at 200 mm3 vs 14.5% at 800 mm3, and 0.42% of NK cells at 200 mm3 vs 10% at 500 mm3), highlighting the impact of tumor burden in TME composition (Figure 5D).