To strengthen the relation between subtypes and TLS, we calculated and explored TLS score, GC B, Tfh, FDC, Plasma, and B cell_score features among RCC patients, and the results showed that C3 presented higher expression of these TLS-related features, including CR2, FCER2, PAX5, CD19, MZB1, JCHAIN, DERL3, CCL19, CCL21, CXCL13, and BLC6. This evidence concerns the gene DERL3 and renal cell carcinoma.