CD8A and neoplasm: This subsequently activates the HIF-1α signaling pathway, leading to upregulation of P4HA1 (a critical regulator of CD8+ T cell differentiation that is highly upregulated in tumor-draining lymph nodes (TDLNs) and hypoxic tumor microenvironments; inhibition of P4HA1 enhances the expansion of progenitor CD8+ T cells while alleviating exhaustion, thereby boosting systemic antitumor immunity).