These are mainly Jak/STAT (Janus Kinase/Signal Transducer and Activator of Transcription), RNAi (RNA interference), Toll via NF-ĸΒ (Nuclear Factor ĸΒ/Dorsal), Imd (immune deficiency) via NF-ĸΒ/Relish, JNK (c-Jun N-terminal kinase), MAPK (Mitogen-Activated Protein Kinases), autophagy, eicosanoid biosynthesis, endocytosis, melanization, and Prophenoloxidase (PPO) (McMenamin et al., 2018) (Figure 7). The gene discussed is NFASC; the disease is Immunodeficiency.