SH2D3C and metastatic malignant neoplasm: Fragments from the set have been crystallographically validated in the SARS-CoV-2 main protease (Mpro) and the nonstructural protein 3 (Nsp3) (Mac1) as well as human glycosyltransferase MGATV, a major enzyme in the mammalian N-glycosylation pathway and a promoter of aggressive metastatic cancers, underscoring the breadth of biological space that can be explored.