Fragments from the set have been crystallographically validated in the SARS-CoV-2 main protease (Mpro) and the nonstructural protein 3 (Nsp3) (Mac1) as well as human glycosyltransferase MGATV, an enzyme in the mammalian N-glycosylation pathway and a promoter of metastatic cancers. Here, SH2D3C is linked to metastatic malignant neoplasm.