RCT: randomized controlled trial, CAPRICORN: Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction, CHARISMA: Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance, BHAT: Beta-Blocker Heart Attack Trial, MI: myocardial infarction, STEMI: ST-elevation myocardial infarction, LVEF: left ventricular ejection fraction, EF: ejection fraction, HF: heart failure, BB: beta-blocker, ACEI: angiotensin-converting enzyme inhibitor, CV: cardiovascular, RRR: relative risk reduction, HR: hazard ratio, IQR: interquartile range. The gene discussed is ACE; the disease is hydrops fetalis.