Furthermore, monocyte-derived dendritic cells (MoDCs) differentiated by GM-CSF can process RA-associated autoantigens, the type II collagen (CII) and cartilage glycoprotein 39 (HCgp39), and present their immunodominant epitopes via MHC class II molecules, initiating autoreactive T cell responses 89-92. The gene discussed is CHI3L1; the disease is rheumatoid arthritis.