This molecular pattern was further validated in CaCl2-induced AAA model, showing analogous suppression of endothelial markers (e.g., Tie1, Pecam1, Vwf, and Cldn5) and induction of mesenchymal markers (e.g., Acta2, Fn1, Fbn1, and Dcn) (Figure S7C). Here, ACTA2 is linked to triple-A syndrome.