VWF and triple-A syndrome: This molecular pattern was further validated in CaCl2-induced AAA model, showing analogous suppression of endothelial markers (e.g., Tie1, Pecam1, Vwf, and Cldn5) and induction of mesenchymal markers (e.g., Acta2, Fn1, Fbn1, and Dcn) (Figure S7C).