SOX18 and triple-A syndrome: Bioinformatics analysis revealed that Sox18 downregulation consistently occurred across multiple AAA models, including CaCl2-induced AAA mice (Figure S6D), DOCA+HS-treated aortic tissues (Figure S8A), AngII-treated ApoE-/- mice (Figure S8B), and human AAA samples (Figure S8C-D), demonstrating conservation across experimental models and human disease.