Notably, downregulation of endothelial markers (e.g., Tie1, Pecam1, Cdh13, Tek, and Vwf) and upregulation of mesenchymal markers (e.g., Fn1, Acta2, Tagln, Lum, Dcn, and Col1a1) were detected in VECs of AngII+HS-induced AAA mice (Figure 4A). This evidence concerns the gene TIE1 and triple-A syndrome.