Flow cytometry (FC) was performed to detect the macrophage polarization using CD86 as an M1 marker and CD206 as an M2 marker in tumor tissues of PDX mice models, and the results showed that the treatment of exosomes over-expressed hsa_circ_0058495 promoted the polarization of M2 macrophages whereas suppressed M1 macrophages (Figure S6E). This evidence concerns the gene MRC1 and neoplasm.