For example, circNEIL3 stabilizes IGF2BP3 by blocking and preventing HECTD4-mediated ubiquitination in glioma 36, and circ_0006646 prevents the interaction of NCL and TRIM21 thus inhibiting the TRIM21-mediated ubiquitinated-degradation of NCL in hepatocellular carcinoma 37. This evidence concerns the gene HECTD4 and central nervous system cancer.