MAPT and Alzheimer disease: We acutely and directly targeted the hippocampal circuit in 16-month-old TgF344-AD rats, which display advanced amyloid and tau pathologies in combination with frank neuronal loss and pronounced impairments in memory, executive function, and long-term extinction memory 27,28 recapitulating the advanced stage of AD, when invasive interventions are most likely to be applied clinically.