For instance, Ko et al. observed that while inhibiting ATG5- and Beclin 1-dependent autophagic programs in human and mouse tumor cell lines significantly enhanced their sensitivity to radiotherapy in vitro by promoting tumor cell death and decreasing clonogenic survival, it switched to a pro-survival role for the tumors on in vivo models by hampering immune cell infiltration and activation 97. This evidence concerns the gene ATG5 and neoplasm.