TP53 and neoplasm: Meanwhile, considering the pivotal role of p53 in post-RT senescence responses as well as its frequent mutation in various tumor conditions, it is important to develop personalized radiosensitization approaches by taking into the p53 mutation status into account, which should enhance the p53 signaling in tumor cells expressing wild-type p53 to promote the beneficial aspects of RT-induced tumor cells senescence while blocking p53-independent cell fate regulatory pathways in tumor cells expressing mutated p53 to achieve cooperative therapeutic benefit.