VEGFA and pancreatic neoplasm: On the other hand, there are also reports that therapy-induced senescence would induce vascular remodeling in pancreatic cancer tissues through promoting SASP-dependent secretion of pro-angiogenetic factors including vascular endothelial growth factor (VEGF), platelet-derived growth factors A and B and fibroblast growth factor 2 as well as MMPs including MMP2/3/7/9/10, leading to the formation of robust vascular networks with activated endothelium that facilitate both the chemotherapeutics delivery and T cell homing 110.