TP53 and neoplasm: In addition, tumor cells are known to activate multiple cell fate mediators including p53 and adenosine monophosphate-activated protein kinase (AMPK) to rebalance iron and lipid metabolism and boost antioxidative capacity by (1) reducing PUFA-PL biosynthesis, (2) alleviating iron overload and (3) elevating antioxidant levels 75-77.