GPX4 and neoplasm: For instance, tumor cells frequently presented upregulated expression of cystine-glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which may support glutathione (GSH) biosynthesis and enhance the detoxification capacity of glutathione peroxidase 4 (GPX4)/GSH system to convert cytotoxic lipid peroxides into non-toxic lipid alcohols, thus contributing to the maintenance of cellular redox homeostasis in tumor cells for blocking post-IR ferroptosis 72, 73.