Indeed, Digomann et al. reported that radioresistant head and neck squamous cell carcinoma (HNSCC) cells showed substantial upregulation of ATG5, a central mediator of autophagosome formation, to activate autophagy as a post-IR pro-survival mechanism, while low ATG5 expression is usually linked with better radiotherapeutic responses and superior HNSCC patient survival 94. The gene discussed is ATG5; the disease is head and neck squamous cell carcinoma.