NLRP3 and neoplasm: From a general perspective, RT can substantially enhance the ROS stress in tumor cells that readily dissociates thioredoxin-interacting protein (TXNIP) from oxidized thioredoxin-1, and the detached TXNIP will further bind to NLR family pyrin domain containing 3 (NLRP3) to trigger inflammasome formation, which is a multimolecular protein complex capable of recruiting caspase 1 and activating its pro-pyroptosis function through autocatalysis 56.