KLK3 and Familial prostate cancer: Localized prostate cancer can be classified into localized low-and intermediate-risk prostate cancer, high-risk localized prostate cancer (Gleason score > 7 and/or prostate-specific antigen (PSA) > 20 ng/mL and/or clinical stage T3/T4), and locally advanced prostate cancer (any T and clinical N1) 1, 2.