Moreover, the expression of the activation marker of CD69 on CD8+ T cells in the tumor tissue of mice from SM-102 sLNPs group was also significantly increased compared to the MCs sLNPs group despite a decrease in CD80/CD86 expression on splenic DCs, indicating that lower inflammatory vectors have stronger potential for mRNA translation and cellular immune response than much higher inflammatory vectors, which was consistent with previous reports 32,62-64. Here, CD80 is linked to neoplasm.