NR3C1 and post-traumatic stress disorder: Moreover, NR3C1 had an indirect effect on the severity of PTSD symptoms mediated through the central operculum (b = -0.01, SE = 0.01, 95% CI = [-0.02, -0.00]), which means that the mutation of the NR3C1 led people to be less vulnerable to PTSD, though enlarging their central operculum.