This phase mirrors the clinical and imaging manifestations typical of myocarditis, thus rendering the differentiation between ACM in its ‘hot phase’ and myocarditis a diagnostic challenge.1-3 We report two cases of young male patients, one with a mutation in the DSP gene and the other with a mutation in the LMNA gene, both presenting features of myocardial inflammation as the first clinical manifestation. Here, DSP is linked to myocarditis.