EGFR and cancer: Given that it is implicated in the proliferation, migration, differentiation, apoptosis, and angiogenesis of cancer cells, EGFR (HER1) is one of the most significant cancer treatment targets.19–22 Due to T790M, L858R, and C797S mutations in the ATP binding pocket of EGFR, predominant drug resistance and limited drug efficacy were detected in 50% of cancer patients.