ZFHX3 and Onset: Interindividual susceptibility likely varies by genetics: canonical atrial fibrillation loci (e.g., PITX2, ZFHX3) and variants in glycation pathway genes (e.g., AGER) may modify the association between acute–chronic glycemic mismatch and new-onset atrial fibrillation (NOAF) (54, 55).