KCNN2 and Cognitive impairment: The pathology associated with KCNN2 mutations was named NEDMAB for NEurodevelopmental Disorder with or without variable Movement or behavioural ABnormalities (OMIM #619725).10 More recently, a variant in KCNN2 has been described in a familial form of essential tremor (ET), associated with anxiety and mild to severe cognitive impairment.11