Our study agrees with microglia’s role in influencing abnormal tau metabolism in the form of altered levels of soluble CSF p-tau127.55 According to the study,55 microglial activation slowed down the neocortical Braak III–VI phases of the disease when tau accumulation, which is closely linked to the onset of dementia, depends on cortical amyloid-β aggregates. The gene discussed is MAPT; the disease is dementia.