APOE and Alzheimer disease: 57,58 The significance of the APOE region in contributing a substantial portion of the association signal for the cell-weighted PRS models was anticipated, given the well-established strong relationship between the APOE locus and the risk of Alzheimer’s disease,59,60 especially for Aβ pathology.61 The association is particularly pronounced in populations mostly of European descent,62 which is consistent with the population under study in our research.