Microgliosis is an important aspect of Alzheimer’s disease, with activated microglia associated with Aβ-plaque deposition.49,50 Taken together, our findings on both Aβ and pTau217 are consistent with a scenario where Aβ-deposition is initiated due to molecular processes that largely involve neuronal activity, but the (downstream) development of tau pathology depends more on molecular processes that involve microglial activity.51,52 Therefore, this study's findings contribute to the understanding of the relationship between Aβ pathology, microglial regulation and altered tau metabolism. The gene discussed is MAPT; the disease is Alzheimer disease.