Disease-causing variants in the neurogenic locus notch homolog protein 3 (NOTCH3) gene lead to Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Syndrome [6], and pathogenic variants in the high-temperature requirement factor A1 (HTRA1) gene are associated with cerebral microbleeds; both disorders of small brain arteries [7]. This evidence concerns the gene NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy.