Following completion of the diagnostic workup and according to International Myeloma Working Group (IMWG) guidelines, the diagnosis of IgE multiple myeloma was confirmed, stage III according to the International Staging System (ISS) harboring t(11;14), with symptomatic disease based on free light chains, fulfilling the Slim-CRAB diagnostic criteria. The gene discussed is IGHE; the disease is plasma cell myeloma.